This is the third session of the Basic/Translational Science Symposium, focused on "The Importance Of Cellular Diversity And Intercellular Communication For Heart Rhythm". It will highlight the role of heterocellular interactions in cardiac arrhythmogenesis and how they may be targeted for anti-arrhythmic therapy.

• Describe the role of heterocellular interactions in arrhythmogenesis.
• Recognize how cardiac disease disrupts heterocellular interactions.
• Appreciate how heterocellular interactions may be targeted for anti-arrhythmic therapy.

Colleen Clancy, PhD
Peter Kohl, MA, MD, PhD

Neuro-cardiac Interactions in Arrhythmogenic Cardiomyopathy
Presenter(s): Induja Perumal Vanaja, MS

Fibroblast-adipocyte-myocyte Cross-talk and Cardiac Arrhythmogenesis
Presenter(s): Joris R. de Groot, MD, PhD

Targeting Heterocellular Coupling as an Anti-arrhythmic Therapy
Presenter(s): Peter Kohl, MA, MD, PhD

Steering Cardiac Electrophysiology with Light-activated Ion Channels in Non-myocytes
Presenter(s): Arjun Deb

Induja Perumal Vanaja:

• Nothing Relevant to Disclose

Joris de Groot:

• Daiichi (Honoraria/Speaking/Consulting Fee - Consulting)
• Bayer Healthcare Pharmaceuticals (Honoraria/Speaking/Consulting Fee - Consulting)
• AtriCure, Inc. (Research (Contracted Grants for PIs and Named Investigators only) - Research)
• Servier (Honoraria/Speaking/Consulting Fee - Consulting)
• Biosense Webster, Inc. (Honoraria/Speaking/Consulting Fee - Consulting)
• Medtronic (Research (Contracted Grants for PIs and Named Investigators only) - Research)

Peter Kohl:

• Nothing Relevant to Disclose

Arjun Deb:

• Nothing Relevant to Disclose

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   4. Know abnormalities of cardiac electrophysiology, including altered ion channel function (inherited and drug-induced) and their effect on action potentials.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   6. Know the mechanisms of cardiac arrhythmias including re-entry, triggered activity, and abnormal automaticity, as well as associated triggers such as ischemia, changes in autonomic tone, and drugs.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   5. Know the principles of cardiac impulse propagation and repolarization.