Cellular Signaling Pathways and Atrial Remodeling in Atrial Fibrillation

Description

This session will cover various aspects of AF-related structural remodeling with a goal of connecting mechanism to therapy.

Learning Objectives

Describe how signaling pathways are activated by stressors associated with AF.
Summarize how signaling pathways contribute to remodeling associated with AF.
Consider possible therapeutics based on signaling pathways driving AF-related structural remodeling.

Session Chair(s)

Anna Pfenniger, MD, PhD
David Van Wagoner, PhD

Presentation

MAPKinases and AF
Presenter(s): Xun Ai, MD

Calcineurin-NFAT Signaling and AF
Presenter(s): WEILAN MO, PhD

JAK-STAT Signaling and AF
Presenter(s): Stanley Nattel, MDCM

Wnt-β catenin Signaling and AF
Presenter(s): Guy Salama, PhD

Disclosures

Xun Ai:

Nothing Relevant to Disclose

WEILAN MO:

Nothing Relevant to Disclose

Stanley Nattel:

Long QT Therapeutics (Honoraria/Speaking/Consulting Fee - Consulting)
GlaxoSmithKline (Honoraria/Speaking/Consulting Fee - Consulting)
Johnson and Johnson (Honoraria/Speaking/Consulting Fee - Speaking and Teaching)

Guy Salama:

Nothing Relevant to Disclose

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

Education Framework

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   4. Know abnormalities of cardiac electrophysiology, including altered ion channel function (inherited and drug-induced) and their effect on action potentials.

Supraventricular Tachyarrhythmias
   --   AFib and Flutter
      --   111. Know the pathophysiological basis and proposed mechanisms of AF and atrial flutter.

Summary


Availability:	No future session


Cost:	FREE


Credit Offered:	No Credit Offered

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