This session will delineate evidence-based approaches to efficient genetic counseling and testing for arrhythmogenic cardiomyopathies, discuss the implications of genotype for risk stratification and shared decision-making for exercise, and describe the rapidly evolving genetic testing and variant classification landscape which is highly relevant to these conditions. Speakers will discuss both ACM/ARVC associated with desmosomal variants and also the less common arrhythmogenic cardiomyopathies caused by variants in DES, LMNA, RBM20, PLN, and other rarer genotypes.

A joint session with National Society of Genetic Counselors (NSGC).

• Select an evidence-based genetic counseling and testing strategy that incorporates the evolution of cardiovascular genetic testing technology and variant classification.
• Summarize the influence of genotype on risk stratification for sudden death in the arrhythmogenic cardiomyopathies and describe gene-specific risk prediction models.
• Describe the heterogeneity of risk associated with exercise among the arrhythmogenic cardiomyopathies and discuss how genotype can inform shared decision-making for exercise participation.

Carol Ko, MS, CGC
Kyla Dunn, MS, CGC

Building a Pipeline for Genetic Testing – What is the Optimal Genetic Counseling and Testing Strategy for ACMs?
Presenter(s): Brittney A. Murray, MS, CGC

Genotype Outperforms Phenotype in Arrhythmic Risk Stratification for the ACMs
Presenter(s): Julia Cadrin-Tourigny, MD, PhD

Genotype Should Inform Shared Decision-making for Exercise for ACMs - the Latest Evidence
Presenter(s): James P. Daubert, MD

Be Prepared – Evolution of the Cardiovascular Genetic Testing and Variant Classification Landscape
Presenter(s): Jodie Ingles, MPH, PhD

Brittney Murray:

• Nothing Relevant to Disclose

Julia Cadrin-Tourigny:

• Tenaya Therapeutics (Honoraria/Speaking/Consulting Fee - Consulting)
• LEXEO Therapeutics Inc. (Honoraria/Speaking/Consulting Fee - Consulting)
• BioMarin, Inc (Honoraria/Speaking/Consulting Fee - Consulting)

James Daubert:

• Boston Scientific (Research (Contracted Grants for PIs and Named Investigators only) - Research)
• Medtronic (Research (Contracted Grants for PIs and Named Investigators only) - Research)
• Medtronic (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Acutus Medical Inc (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• LivaNova (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Affera, Inc. (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Biosense Webster, Inc. (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• CORDIS – Johnson & Johnson (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Springboard (Royalty Income - Author)
• Syneos Health (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Synaptic Medical (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Boston Scientific (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Philips (Honoraria/Speaking/Consulting Fee - Membership on Advisory Committees or Review Panels)
• Rocket Pharma (Research (Contracted Grants for PIs and Named Investigators only) - Research)

Jodie Ingles:

• Nothing Relevant to Disclose

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

Other Arrhythmia Syndromes
   --   Arrhythmogenic Cardiomyopathies
      --   277. Know the methods to manage patients with arrhythmogenic cardiomyopathies, including the pharmacotherapy, ablation, lifestyle modifications and device therapy.

Other Arrhythmia Syndromes
   --   Arrhythmogenic Cardiomyopathies
      --   278. Know how to discuss lifestyle modifications and sports participation in patients with arrhythmogenic cardiomyopathies, using Shared Decision Making.

Other Arrhythmia Syndromes
   --   Arrhythmogenic Cardiomyopathies
      --   270. Know how to diagnose arrhythmogenic cardiomyopathies, including the role of imaging, laboratory testing and genetic testing.