In this oral abstract session, presenters will discuss new insights into potential Long QT syndrome therapy, genetics of idiopathic VF, Long QT syndrome Type 2 in the young, out of hospital pediatric cardiac arrest outcomes, and association of short QT interval and all cause mortality.

• Review new genetic insights into idiopathic VF.
• Describe new insights into Long QT syndrome in the young and potential treatments.
• Summarize new insights into the evaluation of pediatric cardiac arrest and all-cause mortality.

Hiroko Asakai, MD, PhD

Identification of Calcium Release Channel Deficiency Syndrome (CRCDS) Among Patients Diagnosed with Idiopathic Ventricular Fibrillation
Presenter(s): Lucilla Giammarino, Raquel Almeida Lopes. Neves, MD, Sahej Bains, BS, David Tester, BS, Johan Martijn. Bos, MD, PhD, John R. Giudicessi, MD, PhD, Michael John. Ackerman, MD, PhD

Short-Sighted: Short QTc Interval is Associated with Increased All-Cause Mortality but is Rarely Reported
Presenter(s): Chelsea Boyd, MD, Carlos Lodeiro, MD, Stephen J. Dolgner, Alexandra M. Menillo, Bryan C. Cannon, MD, Wilson W. Lam, MD, Santiago O. Valdés, MD, Taylor S. Howard, MD, Jeffrey J. Kim, MD, Tam Dan Pham, Christina Y. Miyake, MD, MS

SGK-1 Inhibition with LQT-1213 Significantly Reduces the QTcF in Patients with Congenital Long QT Syndrome in the Wave I, Part 2 Study
Presenter(s): Philip T. Sager, Michael John. Ackerman, MD, PhD, Saumya Das, MD, PhD, Pirouz Shamszad, MD, Dinesh Srinivasan, PhD, Douglas Wight, Alexandre Brkovic, Wojciech Zareba

Long-QT Syndrome type 2 (LQT 2) in the young: preliminary results of an international registry study
Presenter(s): Matthias Mueller, MD, Anjan Batra, MBA, MD, Charles I. Berul, MD, MS, Adam C. Kean, MD, MPH, Stefan Kurath-Koller, MD, PhD, Joanna Kwiatkowska, Martin J. LaPage, MD, MS, Ayelet Machtei, John Phillips, MD, Anthony Pompa, Shubhayan Sanatani, BS, MD, Yekaterina Spivak, Marie Wilkin, Thomas Paul, MD

Pediatric Out-Of-Hospital Cardiac Arrest Survival to Hospital Admission: In-hospital Evaluation and Outcomes
Presenter(s): Carlos Lodeiro, MD, Emily Grimes, Chelsea Boyd, MD, Sara Stephens, MPH, Alexandra M. Menillo, Taylor S. Howard, MD, Tam Dan N. Pham, MD, Wilson W. Lam, MD, Bryan C. Cannon, MD, Santiago O. Valdés, MD, Jeffrey J. Kim, MD, Cameron Dezfulian, Christina Y. Miyake, MD, MS

Lucilla Giammarino:

• Nothing Relevant to Disclose

Chelsea Boyd:

• Nothing Relevant to Disclose

Philip Sager:

• Thryv Therapeutics (Ownership/Partnership/Principal - Employment)

Matthias Mueller:

• Nothing Relevant to Disclose

Carlos Lodeiro:

• Nothing Relevant to Disclose

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

Diagnostic Testing
   --   Monitoring and Other Noninvasive Diagnostic Testing
      --   24. Know the indications for exercise stress testing, with or without imaging, in the evaluation and risk stratification of patients with cardiac arrhythmias including ventricular pre-excitation, long QT syndrome (LQTS), catecholaminergic ventricular tachycardia (CPVT) and hypertrophic cardiomyopathy, or who are taking class 1C antiarrhythmic medications.

Other Arrhythmia Syndromes
   --   Inherited Arrhythmia Syndromes and Genetic Testing
      --   242. Know the genetic basis of arrhythmias, including genetically based ion channel abnormalities, J-wave syndromes, and inherited cardiomyopathies.