Sex-specific differences in cardiac electrophysiology manifest from the subcellular to patient levels. As a result, they can significantly impact how we diagnose and treat cardiac rhythm disorders in the EP clinic. With speakers composed of both basic researchers and clinicians, this translational session will include state-of-the-art research on the mechanisms of normal and abnormal sex-specific electrophysiology at multiple scales. The aim is to provide the audience with new information that could help to refine clinical EP guidelines for treating cardiac rhythm disorders.

• Summarize mechanisms of sex-specific electrophysiology.
• Describe research approaches to study sex-based differences.
• Outline the consequences for clinical guidelines for diagnosing and treating cardiac rhythm disorders.

Beatriz Trenor, DPhil
Eleonora Grandi, MS, PhD

Sex Differences in Preclinical Models of Cardiac Health, Aging, and Disease
Presenter(s): Howlett E. Susan

Computational Models of Sex-specific Cardiac Electrophysiology
Presenter(s): Jason D. Bayer, PhD

Sex Differences in Activation and Recovery Patterns Revealed by Noninvasive Cardiac Imaging
Presenter(s): Matthijs J. Cluitmans, MD, PhD

Sex Differences in Cardiac Arrhythmias: Clinical Implications
Presenter(s): Anne B. Curtis, MD

Howlett Susan:

• Nothing Relevant to Disclose

Jason Bayer:

• Nothing Relevant to Disclose

Matthijs Cluitmans:

• Philips (Salary from Employment - Research)

Anne Curtis:

• Janssen Pharmaceuticals (Honoraria/Speaking/Consulting Fee - Consulting)
• Medtronic (Honoraria/Speaking/Consulting Fee - Speaking and Teaching)
• Abbott (Honoraria/Speaking/Consulting Fee - Board Membership)
• Milestone Pharmaceuticals (Honoraria/Speaking/Consulting Fee - Consulting)
• Medscape (Honoraria/Speaking/Consulting Fee - Speaking and Teaching)
• Eagle Pharmaceuticals (Honoraria/Speaking/Consulting Fee - Consulting)

To view all Heart Rhythm 2025 Faculty Disclosures, please click here.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   3. Know normal basic cardiac electrophysiology, including the phases and currents that drive the action potential in different cardiac tissues.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   4. Know abnormalities of cardiac electrophysiology, including altered ion channel function (inherited and drug-induced) and their effect on action potentials.

General Concepts
   --   Pathophysiological Basis of Cardiac Arrhythmias and Basic EP
      --   6. Know the mechanisms of cardiac arrhythmias including re-entry, triggered activity, and abnormal automaticity, as well as associated triggers such as ischemia, changes in autonomic tone, and drugs.