The Lead Episode 106: A Discussion of First-in-Human of a Leadless Pacemaker System for Left Bundle Branch Area Pacing

Description

Prashanthan Sanders, MBBS, PhD, FHRS, University of Adelaide is joined by Jenish Shroff, MBBS, MD, Australian National University, and Pugazhendhi Vijayaraman, MD, FHRS, Geisinger Heart Institute, to discuss this first-in-human feasibility study evaluated a novel helix-based leadless pacemaker (LPCSP) designed to achieve left bundle branch area pacing (LBBAP), a capability current LPs lack. The device was temporarily implanted via the internal jugular vein into the interventricular septum in 14 patients, with successful implantation in 10. Electrical performance metrics, including pacing threshold, R-wave amplitude, and impedance, were within acceptable clinical ranges. LBBAP capture was achieved in 5 patients, with no serious device-related adverse events in 85.7% of cases. The study supports the acute safety and feasibility of LPCSP for conduction system pacing.

Learning Objectives

Evaluate a novel helix-based leadless pacemaker (LPCSP) designed to achieve left bundle branch area pacing (LBBAP)

Article Authors and Podcast Contributors

Article Authors

Vivek Y. Reddy, MD, Devi G. Nair, Shephal K. Doshi, Rahul N. Doshi, Milan Chovanec, Leonard Ganz, Leyla Sabet, Chunlan Jiang, Petr Neuzil

Podcast Contributors

Prashanthan Sanders, MBBS, PhD, FHRS, University of Adelaide
Jenish Shroff, MBBS, MD, Australian National University
Pugazhendhi Vijayaraman, MD, FHRS, Geisinger Heart Institute

Faculty and Disclosures

All relevant financial relationships have been mitigated.

Host Disclosure(s):

P. Sanders:
Honoraria/Speaking/Consulting: Boston Scientific, Abbott Medical, Research: Boston Scientific, Abbott, Medtronic, Becton Dickinson, CathRx, Pacemate, Kalyan Technologies, Ceryx Medical, Biosense Webster, Inc., Hello Alfred, Abbott Medical
Membership on Advisory Committees: Pacemate, Medtronic PLC, Boston Scientific, CathRx, Abbott Medical

Contributor Disclosure(s):

P. Vijayaraman:
Honoraria/Speaking/Consulting: Biotronik, Boston Scientific, Abbott Medical, Medtronic, Inc.
Research (Contracted Grants for PIs and Named Investigators only): Medtronic
Fellowship Support: Medtronic

J. Shroff:
Nothing to disclose.

Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):
S. Sailor: No relevant financial relationships with ineligible companies to disclose.
S. Colbert: No relevant financial relationships with ineligible companies to disclose.

Summary


Availability:	On-Demand


Cost:	FREE


Credit Offered:	No Credit Offered