The Lead Episode 165: A Discussion of Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial)

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In this episode of The Lead recorded at HRS2026, host Danesh Kella, MBBS, FHRS is joined by Jeffrey S. Healey, MD, FHRS and Fred M. Kusumoto, MD, FHRS to discuss the journal article, Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial). Together, they review the study findings comparing left atrial appendage closure with medical therapy in patients with atrial fibrillation and discuss the potential implications for clinical practice.

Review the design and key findings of the CLOSURE-AF Trial comparing left atrial appendage closure with medical therapy in patients with atrial fibrillation.
Discuss the comparative considerations of left atrial appendage closure and medical therapy for the management of atrial fibrillation.
Examine the potential clinical implications of the CLOSURE-AF Trial for treatment decision-making in patients with atrial fibrillation.

Podcast Contributors

Host: Danesh Kella, MBBS, FHRS

Guests:

Jeffrey S. Healey, MD, FHRS

Fred M. Kusumoto, MD, FHRS

All relevant financial relationships have been mitigated.

Host and Contributor Disclosure(s):

D. Kella

Honoraria/Speaking/Consulting Fee: Zoll Medical Corporation, MBW Spectrum

J. Healey

Honoraria/Speaking/Consulting Fee: Boston Scientific, Servier
Research: Pfizer, Boston Scientific, Medtronic, Inc.
Speakers’ Bureau: Bristol-Myers Squibb

F. Kusumoto

No relevant disclosures

Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):

S. Sailor: No relevant financial relationships with ineligible companies to disclose.
E. Downward: No relevant financial relationships with ineligible companies to disclose.