Description
In this trial, the incidence of recurrent ischemic stroke, systemic embolism, major extracranial bleeding, symptomatic intracranial hemorrhage, or vascular death at 30 days was estimated to range from 2.8 percentage points lower to 0.5 percentage points higher (based on the 95% confidence interval) with early than with later use of DOACs. (Funded by the Swiss National Science Foundation and others; ELAN ClinicalTrials.gov number, NCT03148457.)
Learning Objectives
- Define minor, moderate and strokes.
- Effect of early as compared to later initiation of direct oral anticoagulants (DOAC) in persons with Atrial Fib who have had an acute ischemic stroke.
Article Authors and Podcast Contributors
Article Authors
U. Fischer, M. Koga, D. Strbian, M. Branca, S. Abend, S. Trelle, M. Paciaroni, G. Thomalla, P. Michel, K. Nedeltchev, L.H. Bonati, G. Ntaios, T. Gattringer, E.-C. Sandset, P. Kelly, R. Lemmens, P.N. Sylaja, D. Aguiar de Sousa, N.M. Bornstein, Z. Gdovinova, T. Yoshimoto, M. Tiainen, H. Thomas, M. Krishnan, G.C. Shim, C. Gumbinger, J. Vehoff, L. Zhang, K. Matsuzono, E. Kristoffersen, P. Desfontaines, P. Vanacker, A. Alonso, Y. Yakushiji, C. Kulyk, D. Hemelsoet, S. Poli, A. Paiva Nunes, N. Caracciolo, P. Slade, J. Demeestere, A. Salerno, M. Kneihsl, T. Kahles, D. Giudici, K. Tanaka, S. Räty, R. Hidalgo, D.J. Werring, M. Göldlin, M. Arnold, C. Ferrari, S. Beyeler, C. Fung, B.J. Weder, T. Tatlisumak, S. Fenzl, B. Rezny Kasprzak, A. Hakim, G. Salanti, C. Bassetti, J. Gralla, D.J. Seiffge, T. Horvath, and J. Dawson, for the ELAN Investigators*
Podcast Contributors
Deepthy Varghese, MSN, ACNP, FNP, of Northside Hospital
Niraj Sharma, MD, FHRS, of Northside Hospital
Kamala P. Tamirisa, of Texas Cardiac Arrhythmia
Disclosures
All relevant financial relationships have been mitigated.
Host Disclosure(s):
D. Varghese: No relevant financial relationships with ineligible companies to disclose.
Contributor Disclosure(s):
N. Sharma: No relevant financial relationships with ineligible companies to disclose.
K. Tamirisa: Honoraria/Speaking/Consulting Fee: Medscape, Abbott, Sanofi
Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):
J. Glenn: No relevant financial relationships with ineligible companies to disclose.
S. Sailor: No relevant financial relationships with ineligible companies to disclose.