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The Lead Episode 60: Safety and Efficacy of Combining Left Atrial Appendage Occlusion With Another Cardiac Procedure

Deepthy Varghese, MSN, ACNP, FNP, Northside Hospital, is joined by Shephal K Doshi, MD Pacific Heart Institute, and Devi G. Nair, MD, FHRS, St. Bernards Medical Center & Arrhythmia Research Group to discuss how the retrospective cohort study examined the safety and efficacy of combining left atrial appendage occlusion (LAAO) with other cardiac procedures compared to isolated LAAO. The analysis, based on data from the National Inpatient Sample database, found similar rates of major adverse cardiovascular events (MACEs) and length of stay (LOS) between the two groups. However, patients undergoing concomitant procedures had higher costs and certain complications were more frequent, such as heart block with atrial fibrillation/atrial flutter ablation and stroke with transcatheter aortic valve replacement. 

Learning Objectives
  • Understand the safety and efficacy of combining left atrial appendage occlusion (LAAO) with other cardiac procedures compared to isolated LAAO
  • Identify the key outcomes, including major adverse cardiovascular events (MACEs), in-hospital mortality, major complications, length of stay (LOS), and total costs associated with combined LAAO procedures
  • Recognize the potential complications and differences in outcomes between various concomitant cardiac interventions, such as atrial fibrillation/atrial flutter ablation and transcatheter aortic valve replacement, when combined with LAAO
Article Authors and Podcast Contributors
Article Authors
Mahmoud Ismayl, Hasaan Ahmed, James V. Freeman, Mohamad Alkhouli, Dhanunjaya Lakkireddy, and Andrew M. Goldsweig 

Podcast Contributors
Deepthy Varghese, MSN, ACNP, FNP, Northside Hospital
Shephal K Doshi, MD Pacific Heart Institute
Devi G. Nair, MD, FHRS St. Bernards Medical Center & Arrhythmia Research Group
Disclosure Policy

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The Heart Rhythm Society is committed to the provision of Accredited Continuing Education (formerly known as Continuing Medical Education (CME)) that is balanced, objective, and evidence based. HRS adheres to the Standards for Integrity and Independence in Accredited Continuing Education of the Accreditation Council for Continuing Medical Education (ACCME) which require that those individuals in a position to control the content of an educational activity (including, but not limited to, planners, faculty, authors, committee members, content reviewers, editors, and staff) disclose all financial relationships with an ACCME-defined ineligible company* within the 24 months prior to the disclosure.


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All relevant financial relationships have been mitigated.

Host Disclosure(s):
D. Varghese: Nothing to disclose. 

Contributor Disclosure(s):
S. Doshi: Research: Biosense Webster, Inc., Abbott Medical, Boston Scientific, Galvanize Therapeutics
D. Nair: Honoraria, Speaking, and Consulting: Medtronic, Biosense Webster, Inc., Boston Scientific, Abbott Medical,

Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):
S. Sailor: No relevant financial relationships with ineligible companies to disclose.
S. Colbert: No relevant financial relationships with ineligible companies to disclose.
Availability: On-Demand
Cost: FREE
Credit Offered:
0.25 ACE Credit
0.25 COP Credit
0.25 ABIM-MOC Point
0.25 ABP-MOC Point
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