William H. Sauer, MD, FHRS, CCDS, Brigham and Women's Hospital is joined by Ezim Ajufo, MD, Brigham and Women’s Hospital and Victor Nauffal, MD, Brigham and Women’s Hospital to discuss the Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants that can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence. 

• To discuss the paper "Ablation for Atrial Fibrillation in Patients With Rare Pathogenic Variants in Cardiomyopathy and Arrhythmia Genes." 

Majd A El-Harasis, Zachary T Yoneda, Katherine C Anderson, Fei Ye, Joseph A Quintana, J Roberto Martinez-Parachini, Gregory G Jackson, Bibin T Varghese, Diane M Crawford, Lili Sun, Hollie L Williams, Matthew J O'Neill, Giovanni E Davogustto, James L Laws, Brittany S Murphy, Kelsey Tomasek, Yan Ru Su, Emily McQuillen, Emma Metz, Carly Smith, Doug Stubbs, Dakota D Grauherr, Quinn S Wells, Gregory F Michaud<span style="font-size:10.8333px">,</span> Pablo Saavedra, Juan Carlos Estrada, Travis D Richardson, Sharon T Shen, Arvindh N Kanagasundram, Jay A Montgomery, Harikrishna Tandri, Christopher R Ellis, George H Crossley, Prince J Kannankeril, Lynne W Stevenson, William G Stevenson, Steven A Lubitz, Patrick T Ellinor, Dan M Roden, M Benjamin Shoemaker

William H. Sauer, MD, FHRS, CCDS, Brigham and Women's Hospital
Ezim Ajufo, MD, Brigham and Women’s Hospital 
Victor Nauffal, MD, Brigham and Women’s Hospital

All relevant financial relationships have been mitigated.

Host Disclosure(s):
W. Sauer: Honoraria/Speaking/Consulting: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific, Research: Medtronic

​Contributor Disclosure(s):
E. Ajufo: Nothing to disclose.
V. Nauffal: Nothing to disclose.