The Lead Episode 127: A Discussion of Remote Screening for Asymptomatic Atrial Fibrillation: The AMALFI Randomized Clinical Trial, LIVE at HRX 2025
Description
Join host and HRS Digital Education Committee Member Melissa Middeldorp, MPH, PhD and her guests Rod Passman, MD, FHRS, and Emma Svenberg, MD, PhD, live at HRX 2025.

In this episode, they explore the AMALFI Randomized Clinical Trial, which evaluated whether remote, wearable-based screening can effectively detect asymptomatic atrial fibrillation in high-risk adults. The discussion breaks down the study design, key findings, and implications for population-level AF screening strategies. It also examines how emerging digital health tools may integrate into routine cardiovascular prevention. 
Learning Objectives
  • Describe the design, patient population, and primary outcomes of the AMALFI Randomized Clinical Trial.

  • Evaluate the effectiveness of remote wearable monitoring compared with usual care for detecting asymptomatic atrial fibrillation.

  • Discuss the potential clinical and health-system implications of implementing large-scale remote AF screening in high-risk populations.

Article Authors and Podcast Contributors
Article Authors

Rohan Wijesurendra, DPhil, Guilherme Pessoa-Amorim, DPhil, Georgina Buck, MSc,Charlie Harper, DPhil, Richard Bulbulia, MD, Alison Offer, PhD, Nicholas R. Jones, DPhil, Christine A’Court, MA, Rijo Kurien, MSc, Karen Taylor, MSc, Barbara Casadei, DPhil, Louise Bowman, MD.



Podcast Contributors

Melissa E. Middeldorp, MPH, PhD

Rod S. Passman, MD, FHRS

Emma Svennberg, MD, PhD

Faculty and Disclosures
All relevant financial relationships have been mitigated.

Host Disclosure(s):

M. Middeldorp
•Nothing to disclose. 
 

Contributor Disclosure(s): 
 
R. Passman

•Honoraria/Speaking/Teaching/Consulting: Janssen Pharmaceuticals, Boston Scientific, CoreMap
•Membership on Advisory Committees: Medtronic, iRhythm Technologies
•Research: AHA Foundation Award, NIH/NHLBI
•Royalty Income: UpToDate, Inc.


E. Svenberg

•Honoraria/Speaking/Consulting: Pfizer, Inc., Johnson and Johnson

•Research: Roche Diagnostics

 

Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):

S. Sailor: No relevant financial relationships with ineligible companies to disclose.

Summary
Availability:
On-Demand
Expires on Sep 29, 2028
Cost:
FREE
Credit Offered:
No Credit Offered