Expert Perspective: Outcomes in Fetuses and Neonates with Severe LQTS-Expert Perspective with Jeremy Moore, MD

Expert Perspective with Jeremy Moore, MD

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Video Summary

A study conducted by UCLA Medical Center examined the clinical outcomes of fetuses and newborns with severe congenital long QT syndrome. The study included 84 patients with long QT type 1, type 2, or type 3. The most common genetic diagnosis was long QT type 3. The study found that long QT type 3 patients had the highest risk of cardiac events and had the poorest transplant-free survival compared to other genotypes. They were also more likely to undergo invasive interventions, experience comorbidities, and have adverse developmental and neurological outcomes. These findings have implications for family counseling and therapeutic decision-making for long QT type 3 patients.

Keywords

UCLA Medical Center

clinical outcomes

congenital long QT syndrome

genetic diagnosis

cardiac events